Xanthine Oxidase Inhibitory Activity of Ethanolic Extract of Ficus Carica Fruit

Hyperuricemia is a purine metabolism disorder characterised by an excess of uric acid in the blood and considered as risk factor for gout, coronary heart disease, hypertension, diabetes, variety other illnesses. Xanthine oxidase inhibitors have key role management hyperuricemia related disorders but multiple adverse effects associated with these agents minimized their chronic use. Ficus carica fruit has been widely used around world therapeutic agent several disorders. In traditional medicine it to treat gouty arthritis effect not scientifically established so far. Objective: This study was conducted assess vitro xanthine inhibition extract. Method: The ethanolic extract evaluated at five different doses its inhibition. inhibitory activity measured spectrophotometrically concentration IC 50 calculated. dose dependant compared standard drug allopurinol. Results: found possess IC50 27.5 µg/ml comparison allopurinol 11.0 µg/ml.Thus can be alternative treatment Conclusion: showed that potential inhibit natural source gout many medical Keywords: Extract (FCE), Oxidase (XO), Inhibition (XOI), Hyperuricemeia (HU).